Gene information
Official symbol ADRB2
Official full name adrenoceptor beta 2
Gene type protein-coding gene
Chromosome5q32
Alias symbolADRBR; BAR; B2AR
Previous symbolADRB2R
Gene familyAdrenoceptors
Resources
Entrez Gene 154
HGNC HGNC:286
Ensembl ENSG00000169252
Vega OTTHUMG00000129933
UCSC uc003lpr.3
GO terms: 103 records
GO Description Category LogP Number of genes Detail
GO:0001659 temperature homeostasis GO Biological Processes -5.81640478 6 More
GO:0001993 regulation of systemic arterial blood pressure by norepinephrine-epinephrine GO Biological Processes -5.63167427 4 More
GO:0002021 response to dietary excess GO Biological Processes -4.59465180 5 More
GO:0002025 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure GO Biological Processes -5.78189015 3 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0003018 vascular process in circulatory system GO Biological Processes -47.1670528 52 More
GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal GO Biological Processes -12.8867024 12 More
GO:0003073 regulation of systemic arterial blood pressure GO Biological Processes -22.2238525 34 More
GO:0003085 negative regulation of systemic arterial blood pressure GO Biological Processes -9.78130162 11 More
GO:0004935 adrenergic receptor activity GO Molecular Functions -7.55914528 5 More
GO:0004939 beta-adrenergic receptor activity GO Molecular Functions -5.78189015 3 More
GO:0005769 early endosome GO Cellular Components -6.25251045 19 More
GO:0006897 endocytosis GO Biological Processes -8.07395492 24 More
GO:0006937 regulation of muscle contraction GO Biological Processes -20.8046481 43 More
GO:0006940 regulation of smooth muscle contraction GO Biological Processes -12.9613663 21 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO Biological Processes -9.16710904 33 More
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO Biological Processes -6.95524830 22 More
GO:0007190 activation of adenylate cyclase activity GO Biological Processes -5.90548425 6 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0008217 regulation of blood pressure GO Biological Processes -35.2019435 60 More
GO:0008227 G protein-coupled amine receptor activity GO Molecular Functions -5.63918224 7 More
GO:0009266 response to temperature stimulus GO Biological Processes -12.1149168 32 More
GO:0009409 response to cold GO Biological Processes -5.06845562 11 More
GO:0009896 positive regulation of catabolic process GO Biological Processes -13.5088608 63 More
GO:0009991 response to extracellular stimulus GO Biological Processes -42.2178323 102 More
GO:0010469 regulation of signaling receptor activity GO Biological Processes -13.5880476 20 More
GO:0010959 regulation of metal ion transport GO Biological Processes -23.6318171 71 More
GO:0022898 regulation of transmembrane transporter activity GO Biological Processes -11.1988499 41 More
GO:0030139 endocytic vesicle GO Cellular Components -10.5530816 23 More
GO:0030278 regulation of ossification GO Biological Processes -11.2759455 26 More
GO:0030501 positive regulation of bone mineralization GO Biological Processes -4.86040077 10 More
GO:0031279 regulation of cyclase activity GO Biological Processes -6.38196333 9 More
GO:0031281 positive regulation of cyclase activity GO Biological Processes -5.63918224 7 More
GO:0031331 positive regulation of cellular catabolic process GO Biological Processes -13.5134767 30 More
GO:0031649 heat generation GO Biological Processes -4.78958087 3 More
GO:0031667 response to nutrient levels GO Biological Processes -41.8130555 98 More
GO:0032147 activation of protein kinase activity GO Biological Processes -11.6086663 28 More
GO:0032409 regulation of transporter activity GO Biological Processes -16.9480646 53 More
GO:0032412 regulation of ion transmembrane transporter activity GO Biological Processes -9.90560995 38 More
GO:0033218 amide binding GO Molecular Functions -9.50305686 47 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0034762 regulation of transmembrane transport GO Biological Processes -31.7284805 100 More
GO:0034765 regulation of ion transmembrane transport GO Biological Processes -18.4305966 71 More
GO:0035150 regulation of tube size GO Biological Processes -44.5138102 41 More
GO:0035296 regulation of tube diameter GO Biological Processes -44.6572858 41 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0040014 regulation of multicellular organism growth GO Biological Processes -9.11971182 17 More
GO:0040015 negative regulation of multicellular organism growth GO Biological Processes -5.22169943 4 More
GO:0042311 vasodilation GO Biological Processes -18.7593927 16 More
GO:0042391 regulation of membrane potential GO Biological Processes -15.0641346 59 More
GO:0042803 protein homodimerization activity GO Molecular Functions -14.2815375 77 More
GO:0043235 receptor complex GO Cellular Components -19.4198369 40 More
GO:0043244 regulation of protein-containing complex disassembly GO Biological Processes -2.18901367 12 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043270 positive regulation of ion transport GO Biological Processes -23.5832054 34 More
GO:0043393 regulation of protein binding GO Biological Processes -7.80142307 15 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0045177 apical part of cell GO Cellular Components -8.17813885 46 More
GO:0045444 fat cell differentiation GO Biological Processes -7.72888419 20 More
GO:0045453 bone resorption GO Biological Processes -4.37707433 7 More
GO:0045761 regulation of adenylate cyclase activity GO Biological Processes -6.38434532 8 More
GO:0045762 positive regulation of adenylate cyclase activity GO Biological Processes -5.34310134 6 More
GO:0045776 negative regulation of blood pressure GO Biological Processes -17.1357953 22 More
GO:0045778 positive regulation of ossification GO Biological Processes -4.90193440 11 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045926 negative regulation of growth GO Biological Processes -11.4342361 38 More
GO:0045932 negative regulation of muscle contraction GO Biological Processes -6.35549828 9 More
GO:0045986 negative regulation of smooth muscle contraction GO Biological Processes -5.72938190 7 More
GO:0046849 bone remodeling GO Biological Processes -4.21089449 9 More
GO:0048638 regulation of developmental growth GO Biological Processes -23.5012496 63 More
GO:0048640 negative regulation of developmental growth GO Biological Processes -7.44784067 20 More
GO:0048771 tissue remodeling GO Biological Processes -15.8777137 28 More
GO:0048871 multicellular organismal homeostasis GO Biological Processes -14.5562171 53 More
GO:0050804 modulation of chemical synaptic transmission GO Biological Processes -15.2260557 60 More
GO:0050873 brown fat cell differentiation GO Biological Processes -7.74299764 11 More
GO:0051098 regulation of binding GO Biological Processes -15.8856010 30 More
GO:0051339 regulation of lyase activity GO Biological Processes -7.52607558 10 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051349 positive regulation of lyase activity GO Biological Processes -6.76353457 8 More
GO:0051380 norepinephrine binding GO Molecular Functions -5.18367662 3 More
GO:0070167 regulation of biomineral tissue development GO Biological Processes -10.3239090 23 More
GO:0071417 cellular response to organonitrogen compound GO Biological Processes -26.3253267 90 More
GO:0071875 adrenergic receptor signaling pathway GO Biological Processes -8.98205881 11 More
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway GO Biological Processes -9.78130162 11 More
GO:0071900 regulation of protein serine/threonine kinase activity GO Biological Processes -19.5794055 63 More
GO:0090066 regulation of anatomical structure size GO Biological Processes -32.7608623 52 More
GO:0090257 regulation of muscle system process GO Biological Processes -33.9441291 67 More
GO:0097746 blood vessel diameter maintenance GO Biological Processes -44.6572858 41 More
GO:0099177 regulation of trans-synaptic signaling GO Biological Processes -15.1793607 60 More
GO:0110149 regulation of biomineralization GO Biological Processes -10.9748263 24 More
GO:0110151 positive regulation of biomineralization GO Biological Processes -4.74345761 11 More
GO:0120161 regulation of cold-induced thermogenesis GO Biological Processes -19.1025541 38 More
GO:0120162 positive regulation of cold-induced thermogenesis GO Biological Processes -19.5569802 32 More
GO:1901338 catecholamine binding GO Molecular Functions -6.56692149 5 More
GO:1901652 response to peptide GO Biological Processes -34.9047734 89 More
GO:1901699 cellular response to nitrogen compound GO Biological Processes -26.9091664 96 More
GO:1904062 regulation of cation transmembrane transport GO Biological Processes -18.6629834 61 More
GO:1990845 adaptive thermogenesis GO Biological Processes -2.79007403 3 More
GO:2000273 positive regulation of signaling receptor activity GO Biological Processes -8.61037442 14 More
KEGG pathways: 9 records
KEGG Description Category LogP Number of genes Detail
hsa04020 Calcium signaling pathway KEGG Pathway -10.4415222 36 More
hsa04022 cGMP-PKG signaling pathway KEGG Pathway -9.74555098 16 More
hsa04024 cAMP signaling pathway KEGG Pathway -7.78464854 30 More
hsa04080 Neuroactive ligand-receptor interaction KEGG Pathway -22.6219922 65 More
hsa04261 Adrenergic signaling in cardiomyocytes KEGG Pathway -3.35554526 8 More
hsa04923 Regulation of lipolysis in adipocytes KEGG Pathway -8.97402692 10 More
hsa04924 Renin secretion KEGG Pathway -9.25913478 11 More
hsa04970 Salivary secretion KEGG Pathway -2.31635881 5 More
hsa05207 Chemical carcinogenesis - receptor activation KEGG Pathway -7.05448873 28 More
Drug-Gene interaction
view
Related drugs: 128 records
Drug name Interaction type Source PMID View
3-o-methylquercetin DTC view
abediterol agonist TdgClinicalTrialChemblInteractions view
albuterol agonist DTCTdgClinicalTrialChemblInteractionsTENDPharmGKBTTD 147571452903243231263841280871029053759155571281550089511752352198006761256907616680159123883382427985118156033 view
albuterol sulfate agonist ChemblInteractions view
alprenolol antagonist DTCTdgClinicalTrialTEND 2439825290324328718802859531 view
arformoterol agonist TdgClinicalTrialTENDTTD 2040608014725487175947271175235217352511160225671747281918501650 view
arformoterol tartrate agonist ChemblInteractions view
atenolol antagonist PharmGKB 1279577616027735 view
azd3199 agonist ChemblInteractionsTTD 25709399 view
bambuterol agonist TTD 20012638326299382238368885698117523521206518818065099 view
bamosiran TdgClinicalTrial view
batefenterol agonist ChemblInteractionsTTD view
bedoradrine sulfate agonist TdgClinicalTrialChemblInteractionsTTD view
benazepril PharmGKB 15554460 view
bitolterol mesylate agonist ChemblInteractions view
bucindolol TdgClinicalTrialTTD view
bunitrolol DTC 2903243 view
bunolol DTC 2903243 view
bupranolol antagonist DTC 290324312606631 view
carmoterol agonist ChemblInteractionsTTD view
carteolol antagonist DTCTdgClinicalTrialTEND 290324315526107117523521349493 view
carteolol hydrochloride antagonist ChemblInteractions view
carvedilol antagonist TdgClinicalTrialChemblInteractionsNCITENDPharmGKB 158610372035231417123352159957012398570128356121236059114764656 view
carvedilol phosphate antagonist ChemblInteractions view
chembl111201 TTD view
chembl116548 DTC view
chembl1256364 DTC view
chembl1257092 DTC view
chembl1465049 DTC view
chembl531322 DTC view
chembl531401 DTC view
chembl579725 DTC view
chembl590927 DTC view
chembl599896 DTC view
chembl604311 DTC view
clenbuterol agonist DTCTdgClinicalTrialTENDTTD 174491611322047123884761685013117207831175235216680159 view
clenbuterol hydrochloride DTC view
clotrimazole DTC view
desipramine antagonist TdgClinicalTrialTEND 1755851889884851741787778168638741184 view
dichloroisoproterenol DTC 2903243 view
dienestrol DTC view
digoxin PharmGKB 22543981 view
dipivefrin hydrochloride agonist DTCChemblInteractions view
disulfiram DTC view
dobutamine hydrochloride agonist ChemblInteractions view
droxidopa agonist ChemblInteractions 9464897180644177969507966628019110970 view
enalapril PharmGKB 17178264 view
ephedrine agonist PharmGKB 316134412677127125730298 view
epinephrine agonist TdgClinicalTrialChemblInteractionsTENDPharmGKB 1762277417597612174178772083748511752352 view
epinephrine bitartrate agonist DTCChemblInteractions view
esmolol hydrochloride antagonist ChemblInteractions view
fenoterol agonist TdgClinicalTrialTENDPharmGKBTTD 620384411730729877795511752352891188116324695 view
fenoterol hbr DTC view
fentanyl PharmGKB 2677127130281924 view
formoterol agonist TdgClinicalTrialTENDPharmGKBTTD 95062481209078776751151466272414720051147304172544117175947271718682117523521868673016432501 view
gsk159802 agonist ChemblInteractions view
hydroxyamphetamine hydrobromide agonist ChemblInteractions view
ici-118551 DTC 2903243 view
indacaterol agonist TdgClinicalTrialPharmGKBTTD 16022567 view
indacaterol maleate agonist ChemblInteractions view
isoetharine agonist TTD 21948594 view
isoetharine hydrochloride agonist ChemblInteractions view
isoetharine mesylate agonist DTCChemblInteractions view
isoproterenol agonist DTCTdgClinicalTrialNCITENDPharmGKBTTD 15151902147520601135833312963495115869551473404615105445107221175235210784181194648861668015914656380 view
isoproterenol hydrochloride agonist DTCChemblInteractions view
labetalol antagonist TdgClinicalTrialTEND 198798186355664810424013615471175235276846712907566 view
labetalol hydrochloride antagonist ChemblInteractions view
las190792 agonist ChemblInteractions view
levalbuterol hydrochloride agonist ChemblInteractions view
levobunolol antagonist TdgClinicalTrialTEND 115724621351412289146361471471175235279281822892662 view
levobunolol hydrochloride antagonist ChemblInteractions view
levosalbutamol agonist TTD view
ly377604 antagonist ChemblInteractions view
mephentermine sulfate agonist ChemblInteractions view
mepindolol DTC 2903243 view
metaproterenol agonist TdgClinicalTrialTENDPharmGKB 287055531685731097373011752352876024510490901 view
metaproterenol sulfate agonist ChemblInteractions view
methacholine PharmGKB 23384627 view
metipranolol antagonist TdgClinicalTrialTEND 287612828852441296772228950371713928417016423 view
metipranolol hydrochloride antagonist ChemblInteractions view
metoprolol antagonist PharmGKB 1602773519637941 view
milveterol agonist TdgClinicalTrialChemblInteractions view
nadolol antagonist DTCTdgClinicalTrialChemblInteractionsTEND 2903243176227748574280798100910433496117523521349493 view
nebivolol hydrochloride antagonist ChemblInteractions view
norepinephrine agonist DTC 29032431150480194648971806441779695071713928417016423966628019110970 view
norepinephrine bitartrate agonist ChemblInteractions view
olodaterol agonist TdgClinicalTrialTTD 20371707 view
olodaterol hydrochloride agonist ChemblInteractions view
oxprenolol antagonist TdgClinicalTrialTEND 95099997882570113118901713928417016423 view
oxprenolol hydrochloride antagonist ChemblInteractions view
penbutolol antagonistpartial agonist TdgClinicalTrialTEND 89826491122419516716244663280987612189902 view
penbutolol sulfate antagonist ChemblInteractions view
pf-00610355 TdgClinicalTrial view
phenylephrine PharmGKB 2677127125730298 view
phenylephrine hydrochloride DTC view
pindolol agonistpartial agonist DTCTdgClinicalTrialChemblInteractionsTENDPharmGKB 197963029032431657444616782741175235216873981666931 view
pirbuterol agonist TTD 894591170533111726002511752352 view
pirbuterol acetate agonist ChemblInteractions view
prilocaine hydrochloride DTC view
procaterol agonist TdgClinicalTrialTENDTTD 124283911682484196836616840631175235215069780 view
procaterol hydrochloride DTC view
propafenone hydrochloride antagonist ChemblInteractions view
propofol PharmGKB 26771271 view
propranolol antagonist DTCTENDPharmGKB 1670640629032431762861111752352161772221668015916082424 view
propranolol hydrochloride antagonist ChemblInteractions view
protokylol hydrochloride agonist ChemblInteractions view
pseudoephedrine partial agonist TEND 171392841044919017016423 view
racepinephrine hydrochloride DTC view
remifentanil PharmGKB 26771271 view
risperidone PharmGKB view
ritodrine agonist TdgClinicalTrialTENDPharmGKBTTD 805983111311067133247812871140117523521976401 view
ritodrine hydrochloride agonist ChemblInteractions view
rolipram DTC 19464886 view
salmeterol agonist TdgClinicalTrialTENDPharmGKBTTD 1182509511250877231263841151642910471277135977715500895117523521980067612897749199323562427985118156033 view
salmeterol xinafoate agonist DTCChemblInteractions view
sevoflurane PharmGKB 26771271 view
sotalol antagonist DTC 809539729032431181538119259968286568515060759 view
sotalol hydrochloride antagonist ChemblInteractions view
spironolactone PharmGKB 22543981 view
terbutaline agonist TdgClinicalTrialTENDTTD 111205941358833187829032062329116754051022687211256987117523521256907620674738 view
terbutaline sulfate agonist DTCChemblInteractions view
tertatolol DTC 2903243 view
timolol antagonist TdgClinicalTrialChemblInteractionsTEND 8103526973086787198021620562490885851059223511752352 view
timolol maleate antagonist ChemblInteractions view
tiotropium PharmGKB 19183167 view
vilanterol agonist TdgClinicalTrialTTD view
vilanterol trifenatate agonist ChemblInteractions view
volanesorsen sodium NCI 2557514 view
Related studies: 11 records
Molecular factor Omics type Application Objective MI type Reference
NM_000024.6:c.491C>T genomics myocardial infarction[diagnosis] myocardial infarction Zee RY et al. J Thromb Haemost. 2006
NM_000024.6:c.-47C>T genomics myocardial infarction[diagnosis] myocardial infarction Bartels NK et al. BMC Med. 2007
NM_000024.6:c.491C>T genomics acute myocardial infarction[diagnosis] acute myocardial infarction Piscione F et al. J Am Coll Cardiol. 2008
NM_000024.6:c.[46G>A;79G>C;491C>T] genomics myocardial infarction[diagnosis] myocardial infarction Zee RY et al. Genetics. 2005
NM_000024.6:c.[-47C>T;46G>A;79G>C] genomics myocardial infarction[diagnosis] myocardial infarction Bartels NK et al. BMC Med. 2007
NM_000024.6:c.[46G>A;79G>C;491C>T] genomics myocardial infarction[diagnosis] myocardial infarction Schurks M et al. Thromb Haemost. 2009
NM_000024.6:c.46G>A genomics myocardial infarction[diagnosis] myocardial infarction Bartels NK et al. BMC Med. 2007
NM_000024.6:c.79G>C genomics myocardial infarction[diagnosis] myocardial infarction Bartels NK et al. BMC Med. 2007
NM_000024.6:c.79G>C genomics ST elevation myocardial infarction[diagnosis] ST elevation myocardial infarction Yilmaz A et al. J Clin Lab Anal. 2009
NM_000024.6:c.79G>C genomics left ventricular dilation[prognosis (bad)] acute ST elevation myocardial infarction McLean RC et al. Cardiovasc Drugs Ther. 2011
NM_000024.6:c.79G>C genomics myocardial infarction[diagnosis] myocardial infarction Xia K et al. Gene. 2017
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